Mousa Dembele, Eric Dier, Dele Alli and Harry Kane will all have to play if Spurs are to have any chance v Dortmund, believes Freund.
Spurs lost that game 3-0 but did so with many of their first-team regulars left out of the starting XI. Tottenham boss Mauricio Pochettino decided he would not gamble his side's Premier League chances against the Europa League and paid the price against a ruthless Dortmund side.
Tonight, if Spurs are to have any chance of turning things around, they may need to reconsider rotating the side.
But one man who played for both Tottenham and Dortmund does not believe this will happen.
Steffen Freund, who joined Tottenham from Dortmund in 1998, believes Spurs will rotate again - mentioning the four players Spurs must play if they are to have any chance of a positive result.
Freund told Sport1 this week:
"I think that coach Pochettino will rotate again. I would be very sorry with that.
"Then Tottenham would have no chance.
"What gives me hope is the fact that Tottenham on Sunday has a home game (v Bournemouth). Maybe Pochettino has therefore chosen not on rotation.
"In defensive midfield Moussa Dembélé and Eric Dier. Offensively Dele Alli and Harry Kane. The four could turn the tie in favour of Spurs."
His belief that Spurs could turn the tie around with the inclusion of these four players is, however optimistic, surely somewhat deluded.
Dortmund looked sensational in the first-leg and the inclusion of these four players may not have majorly impacted on the final result of the tie.
So bringing them in for the second-leg may be an unwise risk.