The former England midfielder has told Spurs' head coach to go for this season.
Pochettino came under fire for resting a number of first-team stars for last Thursday's Europa League trip to Borussia Dortmund, which resulted in a 3-0 hammering for his team.
And, starting with tonight's second leg at White Hart Lane, Wilkins wants to see Spurs winning games first and then handing out rests.
The 59-year-old told talkSPORT's Hawksbee and Jacobs show on Thursday: "We're now at the sharp end of the season whereby you just play them until they drop as far as I'm concerned - play your best eleven.
"The confidence they will gain from winning game after game after game... get the games won and then change the players it's as simple as that."
Asked whether this was an approach adopted by Chelsea during Wilkins' time as the club's assistant manager, he replied: "Absolutely - get the game done and get them out the way."
Spurs, who are also chasing their first league title in 55 years, are currently five points behind leaders Leicester City with eight games remaining.
Despite a productive campaign, the Lilywhites have used the second-fewest players in the Premier League (24), with academy graduates Josh Onomah and Harry Winks regularly featuring in the club's Europa League squads.
Pochettino finds his side particularly stretched up front, with summer signing Clinton N'Jie still absent, and missed out on a January deal for Fulham striker Moussa Dembele, according to Sky Sports.