The Lancashire rivals meet again on Thursday in the second-leg of their Europa League last-16 tie, which Liverpool lead by two goals to nil at the half-way stage.
Jurgen Klopp's side were good value for their win at Anfield six days ago and while Ince acknowledges that United's home advantage could have an impact, he is expecting the Reds to progress tot he quarter-finals.
"They [United] need to replicate their fantastic performance against Arsenal," he told the Alan Brazil Sports Breakfast on talkSPORT on Wednesday. "If they can score a goal in the first half there’s no reason they can’t score a goal in the second.
"But can you stop Liverpool from scoring? Can you stop those front three, [Philippe] Coutinho, [Roberto] Firmino and [Daniel] Sturridge? I’m not too sure, especially with a makeshift defence."
Sturridge and Firmino were both on target in the first leg, with the latter on a spectacular run of form which has seen him score eight goals and set up four others in all competitions throughout 2016.
Last Thursday's tie was the first ever between Liverpool and United in Europe and with both sides struggling to break into the Premier League's top four as thing stand, progressing in this competition could be the pair's best bet of qualifying for next season's Champions League.