The Hammers were desperately unlucky to be held to a 1-1 draw by the Red Devils on Sunday after Payet's sumptuous late free-kick looked to have given Slaven Bilic's men a deserved place in the semi-finals at Wembley.
But Anthony Martial bundled home a scrappy equaliser to set up a fitting last ever FA Cup game at West Ham's Boleyn Ground home of 112 years ahead of their big move to the Olympic Stadium this summer.
One of those fans was former player turned pundit Trevor Sinclair.
The ex winger was an instant hero to Hammers fans after scoring both goals in a 2-2 draw with Everton on his debut in 1998 following a move from Queens Park Rangers.
In a career spanning five years at Upton Park, Tricky Trev - as he affectionately became known on the terraces - scored another 35 goals in over 200 appearances, the most he made at any one club throughout his career.
Sinclair still has a great affection for his old club.
'This team knows it can beat Man United'
"I felt West Ham just about did enough to win it, but it actually could be a blessing in disguise because it gives the club another humongous game under the lights at the Boleyn Ground," Sinclair told whufc.com.
"It will be packed out and if the side can get themselves over the line and into the semi-finals it will be a wonderful evening once again.
"The players will be a bit gutted they didn’t get the job done at Old Trafford but like I say, for me it’s a blessing in disguise.
"This team knows they can go on and beat Man United in the replay so let’s have another great night under the lights and finish the job off."
The winners will play Everton at Wembley on the weekend of April 23rd.
But Sinclair will be back at Upton Park before then when he forms part of a West Ham All Stars squad who will take on the current side for Noble's testimonial later this month.
The game takes place on Easter Monday and will feature other legends such as Rio Ferdinand and Paolo Di Canio.