Could Spaniard make an appearance against his former team?
Arteta, 33, has not played for the Gunners since their FA Cup game against Burnley in late January, and has been a peripheral member of their squad since.
Now heading back to the club where he began his career as a teenager, Arteta may be hoping for a recall, with the Gunners in need of experience in their midfield.
The 33-year-old was quoted by The Express this week discussing that possibility, stating that he was hopeful Arsenal can turn their deficit around.
He said: "In a game, you don’t know what’s going to happen, there could be a penalty and a sending off soon after the start, anything can happen. What’s certain is that we are going to Barcelona with the mindset of making a comeback.”
That belief is what Arsenal need more of if they are to stand a chance of qualifying, or at least avoiding embarrassment against Luis Enrique's formidable side.