The two sides meet in the second leg of their Europa League clash on Thursday.
The Reds are in a commanding position in their Europa League last sixteen clash, having won the first leg 2-0 at Anfield last week.
They were highly impressive in that win against a lacklustre United side, but were left disappointed not to score more against their fierce rivals.
Indeed, the scoreline is a dangerous one for Jurgen Klopp’s side and Can says they will have to score at Old Trafford in order to progress.
"We have to keep going like in the first game," he told liverpoolfc.com.
"We have to press and we have to play to win the game. Of course, we have to try and score again. We don't want to defend for 90 minutes.
"We want to go to the quarter-final, we want to win this competition. We have played a lot of games in it already. It is very important to us."
The Reds will certainly be keen to try and win the Europa League this season given their hopes of making the top four look slim at present.
They are currently 7th in the table and eight points from Manchester City in 4th, and while that is not insurmountable in any regard, it is unlikely they could make up the difference.
The Europa League is more than winnable though, and it may be worth them turning their full attention to that, starting with a win over United on Thursday.