A much-changed Tottenham Hotspur were well beaten by Borussia Dortmund on Thursday.
Spurs were completely outplayed by Thomas Tuchel's side, who are 16 points clear of third in the Bundesliga, which left many fans and pundits to question Pochettino's decision to rest a number of key players, including top scorer Harry Kane.
But Ginola told TalkSPORT on Friday that a wider issue is at fault for Spurs' failings.
"I'm not questioning Spurs or Mauricio Pochettino because he has done a great job this season, bringing new faces from the academy - and again yesterday. I think it's good for the future.
"I'm not questioning that, I'm questioning the attitude of managers towards the Europa League.
"Is it something you want to be a part of? They all seem to want to play in the Champions League so the Europa league seems to be the weakest link."
The former Spurs winger added: "Please, I'm asking UEFA, can you make it a competition that you want to see on a Thursday night, as much as you want to see the Champions League games on a Tuesday and a Wednesday?
"But I will understand Mauricio Pochettino on this one, because for him, winning the league for Spurs this season is the priority."
Tottenham were playing their third game in eight days at Signal Iduna Park, after intense derby matches against West Ham and Arsenal, which have left them five points off the pace at the top of the Premier League.
Spurs face bottom side Aston Villa on Sunday as they attempt to close the gap on leaders Leicester City, but their domestic focus appears to have put paid to their European ambitions this season.
There has been no English representative in the last eight of the Europa League in each of the previous two campaigns, after Chelsea won the competition in 2013 - despite the winner now qualifying directly for the Champions League.