Slaven Bilic takes his troops to Old Trafford this weekend looking to reach the semi-finals in what has already been a wonderful season for the Croat, who replaced Sam Allardyce last summer.
The Theatre of Dreams has arguably been the most daunting of venues in English football for an opposition team over the last two decades.
But Kouyate, whose team-mates go into the contest on the back of a four-match winning streak, is unperturbed by the prospect of visiting the Red Devils, insisting that the Hammers - two points ahead of them in the Premier League - can leave with a win.
“We are all aware of the size of their club; they are one of the biggest teams in the country. We know what to expect from a game there, a nice stadium, good playing surface and a great atmosphere," the towering midfielder told WHUFC.com.
“I have some great memories of playing for the Senegalese national side during the London Olympics in 2012 at Old Trafford, when we played against Team GB and we held them to a 1-1 draw.
"I hope that we can go to Sunday’s game and play in the same way, we know that it won’t be easy, but with the team spirit as it is at the moment, we know that we can get something from the game.”
The East Londoners left Old Trafford with a point when they visited back in December following a 0-0 draw.
This time, though, Bilic and co might be licking their lips as Louis van Gaal's side go into the clash on the back of a 1-0 defeat at West Brom.