Villa lost yet again on Tuesday night, as they were hammered 3-1 at home by Everton, with relegation to the Championship all but a formality now.
Garde's men sit bottom of the table and eight points adrift of safety, and now face the daunting task of a trip to face Manchester City.
City haven't been in top form of late, and were beaten 3-0 by Liverpool in midweek, with Manuel Pellegrini's men losing some steam since the announcement that Pep Guardiola will take charge of the club in the summer.
Their title challenge has effectively fallen apart, and they may not even qualify for the Champions League after Manchester United and West Ham United both closed the gap to fourth place.
They will though be expected to beat Aston Villa today, and pundit Mark Lawrenson has told BBC Sport that he is expecting an 'very inconsistent' City side to hammer beleaguered Villa 3-0.
Lawrenson also admitted that he feels sorry for French boss Garde - who was only appointed back in November - as he believes Garde isn't to blame for Villa's problems, and rued the club's failure to sign any new players during the January transfer window.
"I feel sorry for Aston Villa manager Remi Garde because it is not his fault they are where they are in the table - he did not buy a single player in January," said Lawrenson. "Manchester City are very inconsistent at the moment but it would take an exceptionally bad performance from them to drop any more points on Saturday," he added.
What's your prediction for Manchester City v Aston Villa?