The Irons' number 15 looks set to return against Spurs.
The 26-year-old hitman has been sidelined since November with a thigh injury, having netted five times for the Hammers this season up to that point.
And the Irons' official Twitter account has suggested that the Senegalese - who scored 10 times in 20 Premier League starts last season - is indeed back in Slaven Bilic's squad for this evening.
In short, look who's back! ⚒ pic.twitter.com/AyQHvgxWEr— West Ham United FC (@whufc_official) March 2, 2016
How West Ham fans would love to see Sakho mark his return in goalscoring fashion, though having spent so long out injured, the forward is unlikely to be risked from the start.
Victory tonight could see Bilic's men close in on Manchester City - who face Liverpool away - in the race for the fourth and final Champions League qualification spot.
And Sakho's return could just coincide with a big push to secure Europa League football at a minimum as the Premier League season comes into the final stretch.