Pundit Jamie Redknapp has predicted on Sky Sports News, broadcast on February 26 at 11.15am, that Arsenal will defeat Manchester United in their Premier League clash on Sunday afternoon.
Ten points separate the two clubs in the standings, but they have endured contrasting fortunes in their last two matches in all competitions.
United have recorded comfortable victories over both Shrewsbury Town and FC Midtjylland to progress in both the FA Cup and Europa League respectively.
As for Arsenal, a goalless draw with Hull City was followed by a disappointing 2-0 defeat at home to Barcelona in the Champions League, a result that leaves them on the brink of a sixth successive exit at the last-16 stage of the competition.
However, Redknapp feels that the result in midweek will not have any influence on the game at Old Trafford, suggesting that Arsenal will take more from their triumph over leaders Leicester City.
Redknapp said: "In all of Arsene Wenger's time, he will probably never play against such a weak Manchester United side. They are decimated with injuries - no Rooney, probably no Martial - so the big players won't be playing.
"There could be a few kids playing, although that could give you a bit of danger because they are an unknown quantity, but I don't think Arsenal would have suffered much damage against Barcelona. The Hull result was a poor one but the Leicester game is the key for them because it has given them that real belief that they can still win the title.
"They are going to be going to Old Trafford with their big guns fit and available and I can only see an Arsenal win, as long as they go there and apply themselves in the right way."
In the reverse fixture in October, Arsenal scored three goals in the opening 19 minutes as they comfortably beat Louis van Gaal's men at the Emirates Stadium.
However, the Gunners make the trip to the North-West having failed to beat United in their last eight visits in the Premier League.