Nacer Chadli's goal in Florence meant that Spurs were already ahead on away goals prior to kick off, but Mason added some insurance with a crisp finish to secure a 1-0 half-time lead.
Hugo Lloris 6 - The Frenchman had very little to do throughout, with the exception of the occasional standard save.
Kieran Trippier 8 - Had lots to do due to the adventurous Marcos Alonso at left-back, but the ex-Burnley man did extremely well at both ends. His excellent cross also led to the Lilywhites' third of the night.
Kevin Wimmer 7 - Had to walk a disciplinary tightrope after being booked within 17 minutes, but he did well to stay off the referee's radar after that.
Toby Alderweireld 7 - Continues to impress alongside Wimmer at the heart of Spurs' defence, and he never looked overly troubled by anything that came his way this evening.
Ben Davies 6 - Did very little wrong defensively, but could have perhaps been a little more adventurous going forward.
Eric Dier 7 - Brilliant in both boxes and everywhere in between, with the exception of one or two loose passes.
Ryan Mason 8 - Opened the scoring with a fantastic finish that the absent Harry Kane would have been proud of, before returning to a more reserved, yet still very effective, role. Just edges Man of the Match over Alli.
Christian Eriksen 4 - More or less a spectator for 90 minutes as the Dane watched the game pass him by from right wing.
Dele Alli 7.5 - The all-action midfielder was superb for some 77 minutes, but a moment of stupidity saw him suspended for the first leg of the last 16 after picking up a needless yellow card for simulation. It could well be costly.
Erik Lamela 6 - Curled home a decent second goal from six yards, but it papered over an otherwise ordinary performance from the Argentine, whose set-piece delivery let him and Spurs down all night.
Nacer Chadli 5 - With Kane out injured, Chadli was given an unfamiliar striking role - and it showed. He was isolated for virtually the entire first half through a glaring lack of nous in that position. Slightly improved after the break - and had a well-taken goal chalked off for offside - but Mauricio Pochettino won't rush to use him there again.