The Tottenham boss has been discussing the 22-year-old midfielder.
And his suggestion contradicts Harry Redknapp's surprise prediction that Dier will eventually return to a place within the back four.
The Argentine also explained how positively the youngster reacted to being offered a holding-midfield position during the first training session of the current season.
Pochettino is quoted as telling La Gazetta World by ESPN: "England's midfield is set thanks to the pairing of Dier and Alli.
"On the first day of training I asked [Dier] him to try it out [holding midfield]. He was convinced it would work out and it has."
However, Redknapp told JOE last week: "He's doing a great job in there for Tottenham and it suits the way they play and their setup but I think eventually he will be a great centre-half."
Pochettino's quotes suggest he not only sees Dier as England's future in midfield but also Spurs', hinting he has no plans to return the 22-year-old to defence any time soon.
The beauty of Dier's versatility, of course, is that he can play both positions very well. So far, though, the holding midfield role has suited him better than anything else.
England are in action against the Netherlands in late March at Wembley Stadium, where it will be interesting to see how much Roy Hodgson uses Dier, Alli and Tottenham's other English stars.