Manchester United striker pulled out in the warm up.
Manchester United's injury crisis continues, with Anthony Martial the latest victim.
With United needing a win to go through it is unlikely to be a precautionary measure, with teenager Marcus Rashford thrown in to make his first ever appearance for the club.
#mufc team change: Marcus Rashford has replaced Anthony Martial in the starting line-up after the French striker was injured in the warm-up.— Manchester United (@ManUtd) February 25, 2016
Yet home advantage is negated by a slew of injured ahead of a match against a team who beat them 3-0 earlier this season.
Wayne Rooney, Luke Shaw, David de Gea, Bastian Schweinsteiger and Matteo Darmian are among the first team stars currently out injured, and United will have to hope Martial is able to make a swift recovery.