Gestede could play in Saturday's match at Stoke City after recovering from a hamstring injury, but Grealish, Libor Kozak and Carlos Sanchez have all been ruled out.
Gestede, 27, has been sidelined since last month’s 0-0 draw at Midlands rivals West Bromwich Albion, when he pulled his hamstring just 16 minutes after replacing fellow forward Libor Kozak in the second half.
However, the towering front man could end his four-game absence this weekend at the Britannia Stadium after Garde revealed that he is now back in full training and in contention to feature against the Potters.
Speaking to reporters, the Frenchman said: “I still have many players injured and I’m not sure I have too much choice, unfortunately, [but] Rudy Gestede will be back with the team.”
As well as long-term absentees Jordan Amavi and Adama Traore, who Garde noted is “getting better”, Villa will also be without Kozak, Jack Grealish and Carlos Sanchez for the Stoke clash.
Kozak is not expected to return for a few more weeks after suffering a fractured ankle against West Brom, while Sanchez has featured just once for the club since late-December due to nagging hamstring problems.
Grealish, meanwhile, twisted his ankle in training earlier this month and missed the embarrassing 6-0 home defeat to Liverpool as a result.
The 20-year-old playmaker has been besieged by injury problems lately, limiting him to only two starts and one substitute appearance over the past two months, but Garde is eager to get him back in the side as soon as he is up to full speed again.
“Unfortunately, Jack is struggling with a couple of ankle injuries,” the Villa boss said at his press conference. “This is not the best time for him to show me his desire to get back into the first-team and help the team to fight.
“But as soon as he has resolved his fitness problems, I would like to see a good Jack. I feel sorry for him about it.”