Tottenham Hotspur manager Mauricio Pochettino has confirmed to reporters at his press conference that key striker Harry Kane will miss the Europa League last-32 second leg against Fiorentina because of a broken nose.
The 22-year-old, who has scored 19 goals for Spurs this season, sustained the injury in the FA Cup defeat to Crystal Palace at the weekend, but there were hopes that he would be able to play on Thursday with the protection of a face mask.
However, Kane's manager is unwilling to risk the vital star so early, instead hoping that he will be able to return for next weekend's Premier League clash against Swansea City.
There is another blow for Spurs ahead of Thursday's second leg, with midfielder Mousa Dembele also unavailable after missing training on Wednesday with a groin injury.
Pochettino confirmed, as reported by Sky Sports, that the Belgian, who has been in fine form for the club this season, is also likely to miss the meetings with the Swans and West Ham United in the Premier League, and faces a race against time to be fit for the hugely important North London derby with rivals Arsenal in early March.
The absence of the key duo will be a huge blow as Spurs look for the victory or low-scoring draw which would take them through to the last 16 of the Europa League after a 1-1 draw in the first leg.
Spurs will be praying for a quick recovery for both players as they enter a defining point of their season in both Europe and in their Premier League title challenge, with the game against the Gunners potentially a pivotal moment.
There is also some better news ahead of the Fiorentina rematch, however, as Pochettino will have goalkeeper Hugo Lloris back after he returned to training following two matches out with a shoulder injury.
Argentine winger Erik Lamela is also available after recovering from illness for the match at White Hart Lane on Thursday night.