Staff are being notified today, according to reports.
"We are restructuring our FIC business to make it more suited to future market demand," said a spokesperson for Deutsche Bank.
The cuts will affect less than two per cent of the sales and trading workforce.
It's been a tough year for fixed-income traders, who deal with products such as bonds. The sector tends to fare better during economic downturns, so has struggled as investors move back towards equities.
Morgan Stanley has slashed a quarter of its fixed-income staff, while in January, Goldman Sachs said it would be making adjustments to that part of the business.
The German lender, which is currently going through a restructuring plan, had to reassure investors earlier this month that it would be able to pay an upcoming debt payment.
Co-chief executive John Cryan published an open letter to staff, saying that they should tell clients: "Deutsche Bank remains absolutely rock-solid, given our strong capital and risk position".
However, this did not stop Deutsche's share price slumping below its 2009 low.
Deutsche Bank's share price has fallen almost 50 per cent since co-chief executive John Cryan made his first public appearance in his new role last October.
Full story: Deutsche Bank cuts jobs in London: City A.M.