Arsène Wenger's side are one of only two teams to have handed the shock league leaders a defeat through 25 games so far this season and will be looking to replicate their 5-2 win at the King Power Stadium back in September.
Leicester City were comfortable 3-1 winners at Manchester City last weekend, making them joint-favourites with the bookmakers to lift the title. The result of Sunday's lunchtime kick-off at the Emirates will see those odds shift in either side's favour.
If the Gunners are to pick up all three points here are three match-ups they need to get the better of:
Jamie Vardy vs Gabriel Paulista
The Premier League's top goalscorer has got to fancy his chances up against either Gabriel Paulista or Per Mertesacker in the centre of that Arsenal defence. I think we'll see the Brazilian starting and he has looked error prone ever since replacing the German recently. And should Mertesacker start, does the 2014 World Cup winner have the pace to keep up with Vardy? The Leicester striker has re-found his form of late and his pace, positioning and finishing is poised to cause Laurent Koscielny's centre-back partner some real problems in this game.
Riyad Mahrez vs Nacho Monreal
No player has been involved in more goals than Leicester City's right winger so far this season, contributing to 24 of their 47 goals (14 goals, 10 assists). The Algerian has been devastating down the right wing and causes problems when he cuts inside. Both Nacho Monreal and Francis Coquelin will need to be at their best to keep Mahrez quiet on Sunday.
N'Golo Kanté vs Mesut Özil
This guy is a machine in the centre of the park and looks set to give Mesut Özil and Aaron Ramsey a real battle. The uncapped French midfielder leads the Premier League in tackles and interceptions this season and is a joy to watch from a defensive perspective. N'Golo Kanté adds a little to the attack too in that he has the occasional shot and creates a couple of chances; registering three assists this season. If he can keep Mesut Özil quiet in this match it will go a long way towards Leicester avoiding defeat.
Do you think Leicester City can get a result at the Emirates Stadium on Sunday? Comment below.