Grealish, who can play as a winger or as an attacking midfielder, has a knee problem.
The 20-year-old, though, has urged his Villa teammates to pick up all three points from the Premier League encounter at Anfield.
Gutted I'm not fit for tomorrow's game but ankle is feeling much better now. Come on boys, a win would be lovely #AVFC— Jack Grealish (@JackGrealish1) February 13, 2016
Villa will head into the game against Liverpool on the back of a 2-0 victory over fellow relegation candidates Norwich City at Villa Park.
Remi Garde’s side are at the bottom of the Premier League table at the moment with 16 points from 25 matches.
The Villans are eight points behind 17th-placed Norwich City and are very much in danger of going down to the Championship at the end of the season.
Meanwhile, Liverpool currently find themselves 11th in the standings with 35 points from 25 matches, 12 points behind fourth-placed Manchester City.