The Premier League side are without five first-team players for the upcoming clash with Swansea.
Yannick Bolasie, Bakary Sako and Joe Ledley have been joined on the treatment table by James McArthur and Jason Puncheon after the pair sustained injuries during the Eagles' defeat to Bournemouth in midweek (via Star). While Puncheon will be back in a month, the Star reports that McArthur will miss the rest of the season.
And Pardew has been scratching his head as to why so many of his players have been struck down in recent months.
"We've had a run of injuries I've not really come across too often in my career, particularly the one area," he said, as reported by the Star.
"Our defence has been untouched to a degree and they've produced great performances.
"Our midfield has been fairly strong but our attacking line has really taken a hit and we are fortunate in a lot of ways not to have lost Wilf Zaha given the amount of times he gets fouled."
The current state of the squad has certainly contributed to the side's slide down the Premier League table. Having previously been just outside the top four, a run of seven games without a win in the top flight - including five consecutive defeats - has seen them fall outside of the top half of the table.
While Palace have enough of a cushion to suggest that they will not get dragged into a relegation scrap, Pardew will be hoping that no more of their key men sustain knocks in the coming games as it may completely end their hopes of returning to the top half.