Remi Garde's squad has been hit by a rash of injuries ahead of Tuesday night's match at West Ham United.
Strikers Rudy Gestede and Libor Kozak sat out Saturday’s 4-0 FA Cup fourth round defeat to Manchester City after picking up injuries in the 0-0 draw with West Bromwich Albion and are both set to miss another game.
Carlos Sanchez, meanwhile, has been struggling with a hamstring problem since December’s 1-1 home draw with West Ham and is not expected to feature in the reverse fixture either.
The 29-year-old midfielder briefly returned to action in the 2-0 FA Cup third round replay win over Wycombe Wanderers two weeks ago but was forced off at half-time after suffering a setback.
"I have a lot of players who won't be fit,” Garde told reporters. “I fear that. I will have to check with the doctor.
"I was told earlier that I could bring back either one or two strikers but probably Libor and Rudy won't be fit for West Ham. Carlos neither.”
Elsewhere, Alan Hutton has not featured for Villa since injuring his hamstring in last month’s 3-1 defeat to Sunderland, and despite being named on the bench on the weekend, is facing a race to be fit for the West Ham clash.
"Ashley is struggling with a pain on the calf,” Garde added at his press conference. “Alan is still struggling a little bit with his hamstring despite the fact I put him on the bench for the Man City match.
"Kieran also has a problem with his calf. I will probably have to make changes in the starting line-up."