Back on that sunny day in Cardiff in 2006 Reds legend Steven Gerrard's last gasp thunderbolt rescued Liverpool in that epic final and broke Hammers hearts.
So painful are the memories, many West Ham fans have admitted they have never watched the game again since.
But a decade is a long time in football and now West Ham, on the brink of their move to the 54,000 seater Olympic Stadium, are challenging the Premier League elite.
The sides go head-to-head for the third time this season with the Hammers having already done the double over them.
The ghost of Scaloni
But ahead of the FA Cup match Hammers fans are still haunted by the ghost of Lionel Scaloni, the Argentine right back who's naivety - coupled with a lack of sportsmanship from Liverpool - cost West Ham their first major trophy since 1980.
Scaloni was arguably to blame for Gerrard's famous equaliser after he put the ball out of play for an injured Liverpool player right near his own 18 yard box.
Then when Liverpool threw the ball to him and instantly - and unsportingly - closed him down he panicked and sliced a clearance to the halfway line leading to that goal.
It is a moment West Ham fans, and Liverpool legend Jamie Carragher - who played in the game - will never forget.
'Why didn't he smash it up the pitch!?'
Writing in his Daily Mail column, Carragher said he would have been livid with Scaloni.
"I would still be strangling Lionel Scaloni now if I had been a West Ham player. Oh my God!" Carragher wrote in his column.
"He tried to be like a nice professional. ‘I’ll kick the ball out, someone is injured’. But he kicks it out right next to where he was.
"Why didn’t he smash it up the pitch? It’s the last minute! As if we were going to give it back! We did give it back but I was actually closing him down.
"I told them we were going to throw it to them but the ball was going right to their feet and I was going to close him down. A left-sided centre back pressing on their right back? That’s how mad the game had become."
Liverpool's gamesmanship that day still sticks in the craw of the Upton Park faithful and will only spur them on for a measure of revenge when the two sides clash at Anfield today.