Championship outfit Derby will take on United at home in the fourth round of the FA Cup.
Former United striker Owen does not expect the Rams to lose to Louis van Gaal’s side at the iPro Stadium.
The former Liverpool and Newcastle United striker has predicted the tie to go into a replay.
“United have won the last six FA Cup meetings between the teams but both sides go into the tie on the back of a disappointing result in their respective divisions,” Owen has written on Betvictor.com.
“The Rams will fancy their chances of an upset, and I think their name will still be in the hat for the 5th Round on Monday although they may have to settle for a replay.”
A footnote added: “Michael’s recommendation: Derby County double chance (win or draw) at 5/6.”
Playing at home will give Derby an advantage, and one suspects that head coach Paul Clement will try to field his best available players.
The Rams have been struggling for points in the Championship in recent weeks, but they will be keen on using the FA Cup as a welcome distraction.
United manager Van Gaal is under pressure, and the Dutchman simply cannot afford to get beaten by a side a division below them.
Derby have lost only two of their 14 home games this season, but they are without a win in five Championship matches.
United have lost just one of their last 44 FA Cup games against lower-league opposition, a home defeat by Leeds United in January 2010.