Midfielder Francis Coquelin could return for the clash with the Saints, much earlier than expected.
The French midfielder has been missing for the last two months after picking up a knee injury in the defeat to West Bromwich Albion at the end of November.
He had been expected to be missing out for as much as three months, but has instead returned quicker than expected and is set to provide the Gunners with a huge injury boost.
He has now resumed full training after his injury, and could feature in the squad for the FA Cup tie with Burnley on Saturday, and thus return for the clash with Southampton three days later, reports the Mirror.
That will come as a big boost to manager Arsene Wenger, whose side have sorely missed Coquelin during his absence from the side.
The midfielder has been a big hit in the defensive midfield role since his breakthrough last season, providing a defensive balance that was sorely lacking in the side.
Mathieu Flamini has done an admirable job of replacing him this season, but has struggled to replicate his compatriot’s displays, and fans will be keen to see Coquelin back in the side as soon as possible.