The R's go into the game having won their first match under new manager Jimmy Floyd Hasselbaink last weekend, where they hammered Rotherham United 3-0 away from home.
Now, QPR need to build on that result with another positive performance this afternoon, but will have to do it without star striker Charlie Austin, who left for Southampton last weekend.
Today's opponents are Wolverhampton Wanderers, who also lost their top goalscorer to a Premier League club, having sold Benik Afobe to Bournemouth earlier this month.
Last weekend's defeat to Cardiff City ended a four-game winning run for Kenny Jackett's men, and they must bounce back - but have been dealt another blow with the season-ending injury to promising winder Jordan Graham.
Jackett can however call upon Polish international forward Michal Zyro, who has made a stunning start to life at Molineux, scoring three goals in two Championship games since joining from Legia Warsaw earlier this month.
Former QPR boss Ian Holloway has now had his say on the match, telling Sky Sports that Hasselbaink will need time to impress at Loftus Road after a slow start to life in West London, whilst he also believes that Graham's injury will cause struggles for Wolves in the final third.
Holloway also gave his prediction for the match, stating that the thinks QPR will win the game 2-0, which would move them above Wolves in the table.
"Jimmy Floyd Hasselbaink must be given time to get the right mentality in at QPR," said Holloway. "It was great to see the celebrations with the away fans at Rotherham, but I think that was more relief than anything. That win should give everyone plenty of confidence, especially Matt Phillips, who scored last week and looks a good shout to double up here. He's a streak player - when he gets one, he gets another couple in a row. He has been one of QPR's best players this season - I'm proud of him."
"Wolves have got that right mentality under Kenny Jackett, especially now Benik Afobe got what he wanted and left. You don't need people who don't want to be there. I had it with Charlie Adam - you need to let people go. Players can only achieve their best if they are fully committed. Jordan Graham's injury is a big blow for Wolves - I'm absolutely gutted for him. They'll struggle to create without him. Home win," he added.
What's your prediction for QPR v Wolves?