Intriguingly, both sides drew 3-3 this week - against Arsenal and Newcastle United respectively - but Owen fancies Jurgen Klopp's men to shut out their bitter rivals this weekend.
Indeed, Owen told Colossus Bets: "Man Utd finally found their scoring boots in a 3-3 draw at Newcastle on Monday night but I think it is far too soon to be getting carried away by their goal-scoring prowess - and they could be in for another shut-out at Anfield on Sunday afternoon.
"It could well be that the shackles have come off United’s play at last but I am not convinced and I think Liverpool could see them off 2-0.
"Okay, Liverpool are a hardly a free-scoring side themselves, and were beaten 3-1 at Old Trafford in the autumn, but I feel this is a good time to be playing United, who continue to look vulnerable. Home advantage could be crucial."
Owen played for both Liverpool and United during a stellar but injury-hit career, of course, which divided opinion on the former striker at Anfield.
At one stage, the current pundit held hero status on Merseyside. His move to Manchester clouded things.
In terms of his prediction, though, it's hard to disagree. Manchester United look a side out of form. When Louis van Gaal tries to control his team, they look incapable of scoring goals - but their 3-3 draw with Newcastle shows a lack of defending when they do let loose.
Liverpool couldn't beat Arsenal but they certainly sent out a strong message of defiance against the Premier League leaders to secure a 3-3 draw. If they can score three v the Gunners, it could be more against United.