Villa head into the game having won just once in the Premier League this season, and sit bottom of the table with only eight points from 20 games this term.
Relegation to the Championship is staring Villa in the face, but the FA Cup offers them a chance to take their mind off the relegation battle and try to build some confidence against League Two outfit Wycombe Wanderers.
Gareth Ainsworth's men sit sixth in the League Two table, eight points off the automatic places having won three of their last four matches.
The Chairboys have a storied history in the FA Cup, having reached the semi-finals of the competition in 2001, thanks to Roy Essandoh's goal against Premier League Leicester City at Filbert Street - and they will be hoping to repeat that feat today.
However, pundit Mark Lawrenson has told BBC Sport that he thinks Villa win finally win a game, predicting a 2-0 victory for Remi Garde's men.
Lawrenson did though add that the result will depend on Garde's team selection, suggesting that he should still field a strong side despite their battle against relegation, with a home game against Crystal Palace coming up on Tuesday evening.
"How Aston Villa do against Wycombe will depend on what sort of team Villa boss Remi Garde puts out," said Lawrenson. "Staying in the Premier League is obviously his priority, but you have to bear in mind that he has not won a game yet."
"Villa play Crystal Palace at home in the Premier League on Tuesday, but I still think Garde should play a full-strength team on Saturday. If Villa go out to a League Two team, then their confidence and morale will drop even lower, but I don't think it will come to that," he added.
What's your prediction for Aston Villa v Wycombe?