A place in the fourth round is up for grabs, and the match sees two of this season's high-flyers lock horns at White Hart Lane, having drawn 1-1 at the King Power Stadium in the Premier League back in August.
With a full Premier League fixture list in midweek, it will be interesting to see whether the two managers, Mauricio Pochettino and Claudio Ranieri, choose to rotate their teams and rest some star players, especially following the busy Christmas period.
If that is the case, and the two managers make major changes, pundit Mark Lawrenson has told BBC Sport that he thinks Tottenham's squad depth is the big difference between them and Leicester, and predicts Spurs will win the game 2-0 and advance into the fourth round of the FA Cup.
However, Lawrenson still states that he doesn't think Tottenham can win the Premier League, with Spurs currently sitting six points adrift of league leaders Arsenal.
"Tottenham against Leicester is very interesting and the longer the season goes on, the more impressive Spurs look," said Lawrenson. "They have a very good chance of making the top four, but I don't think they can win the title. Tottenham manager Mauricio Pochettino strikes me as a guy who will put all of his eggs in one basket and concentrate on the Premier League, and Claudio Ranieri is likely to do the same with Leicester."
"Spurs have got a squad that allows Pochettino to make changes, as they have shown in the Europa League, and that could be the difference on Sunday because I am not sure the Foxes have the same," he added.
What's your prediction for Spurs v Leicester today?