The Cottagers will take on their Championship rivals at the Hillsborough Stadium in the third round of the FA Cup on Saturday afternoon.
Fulham will head into the tie the back of a 1-0 defeat to Wednesday at Craven Cottage in the Championship.
The London outfit are in the wrong end of the table at the moment and are in danger of getting relegated to League One at the end of the season.
The Cottagers are currently 19th in the league table with 27 points from 25 matches, just six points above the bottom three.
Meanwhile, Wednesday are having a fabulous season and are in the running for a top-six finish in the Championship.
The Owls are seventh in the league table at the moment with 39 points from 25 matches, just two points behind sixth-placed Ipswich Town.