The Reds will take on West Ham away from home at the Boleyn Ground in London, and former Liverpool winger Barnes has backed the visitors to register a 2-1 win.
“West Ham showed signs of improvement with a win in their last game against Southampton, but prior to that they had been a little predictable in terms of attacking,” the former England international has written on Titanbet.co.uk.
“I think Liverpool will have too much for them with an away game suiting Klopp’s team. Goalscorers – Christian Benteke and Andy Carroll.”
West Ham returned to winning ways in the Premier League on Monday evening when they got the better of Southampton 2-1 at home.
Slaven Bilic’s side will head into the game full of confidence, although they will not find it easy against a Liverpool side who are picking up results at the moment.
Liverpool will head into Saturday afternoon’s game on the back of a 1-0 victory over Sunderland away from home at the Stadium of Light.
It was the Merseyside outfit’s second successive win in the Premier League, and manager Jurgen Klopp will be determined to make it three in a row.
Liverpool have won on seven of their last 10 visits to the Boleyn Ground, with the Hammers winning the other three.