The Saints go in to the game having hammered Arsenal 4-0 on Boxing Day, with Ronald Koeman's men flipping the form book on its head to thrash the title contenders.
The much-criticised Shane Long came in for injured hitman Graziano Pelle, and proved his doubters wrong with a superb two-goal performance, but the game will be remembered for right back Cuco Martina's stunning long range strike to open the scoring.
Today, Southampton travel to East London to take on West Ham United, who are now eight Premier League games without a win after Saturday's 1-1 draw at Aston Villa.
The injuries to key players Winston Reid, Dimitri Payet, Manuel Lanzini, Victor Moses, Diafra Sakho and Andy Carroll have really taken their toll on the Hammers, and with five draws in a row, manager Slaven Bilic really needs a victory.
He will be hoping that it comes today, but pundit Mark Lawrenson doesn't see it panning out that way, having told BBC Sport that he thinks Southampton will win 2-0.
Lawrenson feels that, whilst West Ham are in no danger this season, their injury problems make a win unlikely right now, and he also believes that Southampton's more physical brand of football against Arsenal will give them momentum.
"Southampton looked like they had had the hurry-up from Ronald Koeman when they thrashed Arsenal on Boxing Day night," said Lawrenson. "They have been a bit too nice and very inconsistent but the Arsenal game was a significant win. They convinced themselves that they need to be nasty in footballing parlance, more bullish."
"West Ham have drawn their last five and are without some key players and are just nursing their way through until Dimitri Payet and Diafra Sakho are back fit. They will be fine this season but I can see the Saints rolling them over," he added.
What's your prediction for West Ham v Southampton?