Hackers changed the name of his account to "Martin The God" and sent out a series of tweets on Sunday .
"We have been working with Twitter to get it fixed," Craig Stevens, a spokesman for the former chief executive of Turing Pharmaceuticals, said in an email to Reuters.
One tweet said: "I am now a god"
Another said: "Anyone want free money? Willing to donate hundreds of thousands to charities before I go to prison..."
Shkreli caused outrage earlier this year when he hiked the price of Daraprim , a drug often taken by people with AIDS, from $13.50 to $750 a tablet overnight while he was the boss of Turing Pharmaceuticals.
But Shkreli stepped down as chief executive of the company after he was arrested on securities fraud charges related to the running of his hedge fund MSMB Capital Management.
Before his account got hacked, Shrekli took to Twitter on Saturday to defend himself , saying the allegations against him "are baseless and without merit".
As well as a series of expletive-riddled tweets, hackers also made reference to the Wu-Tang Clan album that Shrekli paid $2 million for – the only copy the group was selling to the public that was bought by the ex-pharma executive.
"Giving away WUTANG album RT for a chance to win," the hackers tweeted.