The Argentine has played just once this season for Spurs.
Tottenham Hotspur have impressed in the Europa League this season and will now be hoping for retribution against the side that knocked them out of the competition last season.
Fiorentina got the better of Spurs last season, 3-1 on aggregate.
One man who is likely to want to forget that tie is Federico Fazio.
The Argentine struggled in Italy and has never really recovered since. His last game in the Premier League coming last season and the former Sevilla star looks surplus to requirements at Spurs.
Now it is believed that Fiorentina are in fact interested in ending his White Hart Lane spell.
SportItalia reports La Gazzetta as stating the Florence side are keen on the player. As he has not featured for Spurs in the Europa League this term he would not be cup-tied and if he did arrive at Fiorentina could even feature against Spurs in the Europa League.
The Argentine international has played just once this season, in a Capital One Cup defeat to North London rivals Arsenal.
The arrival of Toby Alderweireld has seen him fall even further down the pecking order and Fiorentina are likely to be welcome to him.