Pundit Mark Lawrenson has told BBC Sport that he thinks Tottenham will lose again this weekend, predicting a 2-1 win for Southampton.
Argentine boss Pochettino faces a return to his former club Southampton, as does defender Toby Alderweireld as the duo prepare for a South Coast reunion.
The Saints haven't been in great form of late, with no wins in the last four games and only two goals scored in that time, meaning Southampton have dropped to 12th in the Premier League table.
Ronald Koeman's men need a response this weekend, and will be hoping that they can make it two defeats in a row for Tottenham later today.
Ahead of the match, pundit Mark Lawrenson has had his say on the game, telling BBC Sport that he thinks Southampton will win the game 2-1.
Lawrenson claims that Tottenham won't find it easy to bounce back and recover from their defeat to Newcastle, and believes the goal-shy Saints will find their shooting boots once again.
"Southampton have only taken one point from their last four league games, and this is not the first time they have gone through a spell where they do not look like scoring," said Lawrenson.
"Tottenham have been in much better form but their long unbeaten run was ended by Newcastle last week and it will not be easy for them to bounce back from that straight away," he added.