The champions have been linked with moves for John Stones and Seamus Coleman in recent weeks.
While they have struggled this season, not many would have anticipated Roman Abramovich wielding the axe on the Portuguese maverick for a second time.
The failure to lure John Stones away from Goodison Park was the start of a number of failures by both Chelsea and Mourinho this season.
That has not been the end of their interest though, with constant reports that they would return with an even bigger bid for the young defender emerging ever since.
He is not the only Everton star they reportedly have their eye on, with TuttoMercatoWeb this week claiming that right back Seamus Coleman could be making a move to the Capital in future.
With Mourinho now gone and a new manager coming in, a change in transfer policy is sure to follow, with new ideas sure to replace the old ones.
That will be welcome news for those at Goodison Park, who have sat mostly quiet while their big stars were linked with moves away.
Roberto Martinez has been insistent that none of his key men would be leaving any time soon, but even he would have surely been growing slightly concerned that the opposite would actually be true should big enough offers be made.
That interest is likely to die down now though with Mourinho gone, something which be warmly welcomed at all levels at Goodison Park.
They may revive that interest in future, with Stones set for a bright future, but for now, he and Everton can focus on improving, without the added distraction of Mourinho's interest in his stars.
So while the Premier League will likely miss a man who has been one of its biggest characters over years, its loss is very much Everton’s gain.