QPR go into the game having earned a 0-0 draw against Burnley in Jimmy Floyd Hasselbaink's first game in charge, and he will be in front of the Loftus Road crowd again on Tuesday night.
This time though, QPR face a tough test, with Championship league leaders Brighton and Hove Albion arriving in West London with a stunning unbeaten run.
Chris Hughton's men have yet to lose in their 20 games so far this season, with 11 wins and nine draws, leaving them top of the table - something few pundits or even supporters could have predicted before the start of the season.
This promises to be a close encounter at Loftus Road, and ex-R's boss Holloway is backing his former club to produce a shock result and beat Brighton.
Speaking to Sky Sports, Holloway has claimed that, with the Loftus Road crowd behind them, QPR will have enough to claim all three points.
Holloway also stated that he believes midfielder Alejandro Faurlin - who has suffered injury hell in recent years - will be Hasselbaink's surprise match-winner in a 1-0 victory, tipping the Argentine to score the winning goal.
"This is THE game I'm looking forward to on our 10 in 10 adventure and I think the home crowd will rock the house down at Loftus Road to the extent that Brighton's magnificent unbeaten run will come to an end," said Holloway. "That will be a huge incentive for Jimmy Floyd Hasselbaink, the players and the fans. They played well for long periods against Burnley and that'll give something for Jimmy to build on."
"I have first-hand experience of when that place comes alive. When we beat Oldham under the floodlights in the play-off semi-final all those years ago. Wow. It was frightening atmosphere and a night I'll never forget. I love going back to see the Super Hoops. If anyone deserves a goal in a big game it's Alejandro Faurlin. What he's been through to get back to somewhere near his best is amazing to see. He'll win it for the R's with a free-kick or a penalty if Charlie Austin isn't playing," he added.