The Hammers are in the midst of an injury crisis, with Winston Reid, Dimitri Payet, Manuel Lanzini, Victor Moses and Diafra Sakho all on the treatment table for some time.
This is manager Slaven Bilic's biggest test since taking the job over the summer, and having gone five games without a win, this is something of a tough time for West Ham.
Today, they take on a Stoke City side who have earned plenty of plaudits for their 2-0 win over Manchester City last weekend, as the likes of Bojan, Marko Arnautovic and Xherdan Shaqiri all starred in the Potters' victory.
Mark Hughes must now attempt to guide his side to another victory, in what would be a fourth win in five games - but Mark Lawrenson doesn't believe either side will win.
The pundit has told BBC Sport that he thinks the two teams will draw 1-1 at Upton Park later today, even with West Ham's injury problems.
Lawrenson added that he saw West Ham's 0-0 draw at Manchester United last week, and was particularly impressed with Hammers striker Andy Carroll.
"I was at Old Trafford last week for West Ham's 0-0 draw with Manchester United and was very impressed with Slaven Bilic's side," said Lawrenson. "Andy Carroll was a threat up front, the Hammers had the better chances and they were decent at the back too."
"Stoke were also very impressive as they beat Manchester City last week, and it will be interesting to see if they go for it on Saturday as much as they did in that win," he added.
What's your prediction for West Ham v Stoke?