Tottenham have already booked their place in the knockout stages of the competition, meaning that they have little to play for other than pride.
As a result, Pochettino is keen to tinker with his line-up, but the Argentine boss does not want to make wholesale changes.
"There will maybe be more changes than there were for the recent 1-0 win over Qarabag, but not too many," he said.
"The squad we have is strong enough to challenge in different competitions."
One of the players who could miss out against Monaco is Harry Kane.
The England international striker has been required to play in every one of Tottenham’s matches so far this campaign, but he could be left on the bench against the Ligue 1 outfit.
"He [Kane] is in the squad for tomorrow, but we need to assess the situation," Pochettino added.
Tottenham have been boosted by the news that both Nabil Bentaleb and Nacer Chadli are available for selection in the contest.
The pair have both missed a sizeable amount of football due to injury recently, but it seems that they could return at White Hart Lane in midweek
Tottenham and Monaco drew 1-1 when they met back in October.