The winger came on as a replacement for the injured Moses in the draw with Manchester United.
Antonio has not featured much for the Hammers since joining from Nottingham Forest on deadline day in September, with the likes of Moses and Manuel Lanzini preferred ahead of him.
He was called upon on Saturday against Manchester United though, with Moses heading off with an injury during the first half at Old Trafford.
He was just as effective as the on loan Chelsea man had been in the game, but Nicholas says he is currently lacking that Premier League knowledge that Moses offers.
“Antonio came on and he’s got good pace, but he hasn't quite got the savvy that Moses has got to make things and create things.”
While Antonio showed he can step up should Moses be out for an extended period, manager Slaven Bilic will be hoping the on-loan forward hasn’t picked up a long-term injury.
The Hammers have suffered several injuries to their forward stars of late, with Dimitri Payet, Manuel Lanzini, Diafra Sakho and Enner Valencia all currently on the treatment table.
The side are firmly in need of Moses to be their creative force, and losing him for an extended period could be a big blow to any European hopes they harbour at present.