Not only that they also lost his replacement Enner Valencia, himself only just back from a three month injury, and he will sit out at least another month.
They say bad luck comes in threes and true to form the East Londoners were dealt another huge blow when key striker Diafra Sakho picked up a 'significant' thigh injury in the 1-1 draw with West Bromich Albion last time out, as confirmed on the club's official site.
He too faces a lengthy spell on the sidelines and it leaves West Ham shorn of their three most potent attackers.
Although Bilic does have back-up options in midfield he could well regret his recent decisions to let two impressive youngsters leave the club on loan.
Last week talented midfield playmaker Martin Samuelsen, who was signed from Manchester City in the summer, was allowed to join Peterborough United until January 2nd despite impressing in pre-season and being tipped to challenge for a first team spot.
He made an instant impact on his debut at the weekend, setting up a goal and wowing the crowd as Peterborough beat Scunthorpe 4-0.
With Payet out and Alex Song some way off match fitness Samuelsen could well have provided some youthful exuberance and guile in the heart of the Hammers' midfield.
Another young player who has been knocking the door of the first team is Elliot Lee, son of former England international Rob.
He too was allowed out on loan at the same time as Samuelsen to League One side Blackpool, again despite impressing in pre-season and scoring on his full competitive debut against FC Lusitans in Europa League qualifying.
The 20-year-old found the net three times during an 11-game loan spell at League Two club Luton Town last season.
Lee offers pace and is a fox in the box type striker, something West Ham do not currently possess.
After injuries to Valencia and Sakho he could well have found himself in the first team picture for the next month.