The Aston Villa boss says his side will be prepared for Ronald Foeman's team's desire for revenge this weekend.
The Saints were beaten 6-1 by Liverpool in the Capital One Cup on Wednesday evening, with the Reds running riot at St Mary’s.
It was a seriously demoralising performance from Ronald Koeman’s side, who had started the game positively as Sadio Mane put them 1-0 in front very early on.
They will be keen to prove that result was just a minor blip against Villa on Saturday, and Garde is wary of the backlash his side could face.
"I'm not in a position to say it's a good thing for us that they were thrashed on Wednesday," he told avfc.co.uk.
"They'll have time to recover before Saturday. I'm expecting a very tough game because they'll want to react and they'll want to win that game in front of their fans.”
"The defeat against Liverpool was probably hard for them and they will probably be out for revenge on Saturday. We will be prepared for that."
While Villa will be keen to avoid defeat, they also know that they will need to start picking up points sooner rather than later.
They are currently bottom of the Premier League table with just five points to their name, and seven points adrift of safety, with Sunderland on 12 points in 17th place.
Whether they can do that against Southampton remains to be seen, with Koeman’s side eyeing up Europe once again this season.
They are currently 10th in the table, and just three points outside of a Europa League place, with Liverpool sat sixth on 23 points.