The midfielder picked up a knee injury in the 1-1 draw with Norwich City.
The midfielder picked up an injury in the recent 1-1 draw with Norwich, with it having been revealed that he has damaged knee ligaments.
There were fears he could be absent for a prolonged period, and those look set to come true, with it possible that he could be missing until spring 2016.
The Gunners are still assessing the injury at this moment in time, but the Guardian reports they are resigned to losing the Spaniard, and are even worried it could be for longer than the three-month period cited.
The loss of Cazorla is the latest in a number of big injuries to have hit Arsenal and seriously hamper their title challenge this season.
Star turns Alexis Sanchez and Laurent Koscielny also injured themselves at Carrow Road, with both unable to finish the game.
While the Frenchman’s injury doesn’t look to be a serious one, there are fears Sanchez could be sidelined for between three and four weeks.
They join the already lengthy injured list at the Emirates, with Mikel Arteta, Francis Coquelin, Kieran Gibbs, Tomas Rosicky, Theo Walcott, Danny Welbeck and Jack Wilshere all also on the treatment table.