The Spaniard is a considerable distance ahead of his nearest rival.
The midfielder - who passed the landmark during the Gunners' disappointing draw with Norwich City on Sunday - is top of the table by a considerable distance.
While Manchester City's Fernandinho, Chelsea's Cesc Fabregas and Cazorla's teammate Mesut Ozil join the 30-year-old in the top five, it is a perhaps surprising name that is the Spaniard's nearest challenger, in Bournemouth's Andrew Surman. The Cherries midfielder is still some way off top spot, however, having made over 200 fewer successful passes than Cazorla.
The former Malaga man's place at the top of the table highlights just how effective he has been since he has been dropped into a holding role alongside Francis Coquelin.
The position has allowed Cazorla to get on the ball earlier, and either pick out a pass or go on one of his runs that often create gaps for one of his teammates to exploit.
Despite reaching the landmark, Cazorla will be focused on getting back to fitness - after the Independent suggested that he may well miss the Gunners' upcoming games with Sunderland and Olympiakos after picking up a knock against the Canaries - and helping Arsene Wenger's side get their season back on track after a couple of poor results.