The 29-year-old Colombian failed to impress in Saturday's 3-2 home defeat to the Hornets.
Remi Garde’s men went behind after 17 minutes at Villa Park when Odion Ighalo opened the scoring, before Micah Richards equalised just before half-time with a thumping header from Jordan Veretout’s free-kick.
Watford restored their advantage with 20 minutes left through an Alan Hutton own goal, however, before they made it a two-goal cushion in the 85th-minute when Troy Deeney beat Ciaran Clark in the air to head past Brad Guzan.
Jordan Ayew gave the hosts some hope of a comeback with a late strike, but Villa ultimately failed to take advantage of the subsequent 10 minutes of stoppage-time following Heurelho Gomes’ earlier concussion.
Garde’s side enjoyed more possession [65 per cent] and certainly looked dangerous at times, but it was careless errors and defensive miscues which once again ended up costing them a share of the points.
Sanchez was one of the players guilty of some sloppy play, as he continually gave away possession in his own half from his holding midfield position and disrupted Villa’s tempo with his ponderous approach on the ball.
Speaking on Sky Sports’ Soccer Saturday after watching the match, Le Tissier was particularly critical of the Colombia international and stressed that the Villa defence on a whole have to improve if they want to avoid the drop.
"Villa give chances away too easily and the ball away far too easily in their final third," the former Southampton forward said. "Carlos Sanchez must have given the ball away in the first half two or three times right on the edge of his box.
"I think one of the goals might have come from a poor clearance of his, and [Etienne] Capoue missed a sitter after he dawdled on the ball on the edge of the ball. They just weren’t at the races defensively."
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Sanchez, 29, has made 46 total appearances for Villa since signing from Spanish club Elche in August 2014 for a reported £4.7 million fee, having impressed during Colombia’s run to the World Cup quarter-finals in Brazil.
The 62-times capped veteran has been inconsistent during his time in England so far, however, and failed establish himself as a regular starter under either former manager Paul Lambert or predecessor Tim Sherwood as a result.
New boss Garde recently praised him for his strength and physicality, while adding that he adds more on the defensive side of the ball than his fellow Villa midfielders, but his latest performance was a reminder of why both Lambert and Sherwood often played Ashley Westwood ahead of him.
His tendency to get far too adventurous with his passing has been his main problem, and while he is seemingly in Garde’s good books for the time being, it might not be long before he is relegated back to the bench if he cannot keep things simple and let others do the creative work.