Rangers, who got relegated from the Premier League at the end of last season, are 15th in the Championship table at the moment with 20 points from 17 games.
The London outfit will head into the match against Leeds on the back of a 1-0 defeat to Middlesbrough away from home at the Riverside Stadium in the league.
Meanwhile, Leeds will head into the encounter against QPR on the back of a 1-0 defeat to Rotherham United at Elland Road in the Championship.
The defeat to Rotherham at home left the Whites 16th in the league table with 19 points from 17 matches.
The West Yorkshire outfit are just four points above the bottom three, and the risk of getting dragged into a relegation dogfight is still there.
Queens Park Rangers XI:
Leeds United XI: Silvestri, Wootton, Bellusci, Cooper, Taylor, Dallas, Bridcutt, Cook, Mowatt, Antenucci, Wood
Subs: Peacock-Farrell, Byram, Adeyemi, Murphy, Botaka, Erwin, Doukara