Sanchez has been a hit in England since joining the Gunners from Barcelona in 2014, playing a host of games and consistently performing to very high standards.
Vardy, likewise, has experienced a fabulous last 18 months in the Premier League, and his rise to prominence has prompted England boss Roy Hodgson to draft him into the international scene.
The amount of games in which both players have featured is remarkable considering their full-throttle style of football, and Wenger says the duo face the same potential problems.
“When he [Sanchez] does anything he does it at 100 per cent so you have to trust him to know his own body,” Wenger was quoted as saying.
“You see signs of exhaustion with him after every game because he always gives 100 per cent and you think ‘he’s dead now’. But then he recovers and two days later he is fine and ready to go again.”
“He plays with a very committed and explosive style. Jamie Vardy is a bit similar.”
“When he goes, he is like a lion. He has to catch his prey in the first 200 metres. If he doesn’t get there by that point, he’s dead. He is that kind of a killer. When he goes, it is to kill and after that he has to stop.”
“It is all linked to a mixture of flexibility, the sense of how far you can push your body and the sensitivity of when you have to ease off on your bodyweight.”
Vardy’s direct style of play has certainly helped his cause this season, with the England international breaking records for scoring at least one goal in his last 10 successive league matches.
His 13 Premier League goals to date sees Leicester top the Premier League table heading in to this weekend’s encounter with Manchester United, an astonishing achievement from the Foxes.
Vardy, like Sanchez, however, is susceptible to picking up injuries and similarly with Arsenal, his absence could have a big impact on his team’s ability to pick up results were he to be sidelined at any point.