The Saints will take on City away from home at the Etihad Stadium in the Premier League on Saturday afternoon.
Southampton currently find themselves eighth in the Premier League table with 20 points from 13 matches.
The Saints are six points behind Arsenal, who are fourth and occupy the final Champions League spot.
Ronald Koeman’s side will head into the match against City on the back of a 1-0 defeat to Stoke City at St. Mary’s Stadium.
Meanwhile, City are third in the league table at the moment with 26 points from 13 matches, just two points two behind leaders Leicester City.
The Citizens will head into the game at the Etihad Stadium on Saturday afternoon on the back of a 1-0 defeat to Juventus away from home at Juventus Stadium in the Champions League Group D.
Last weekend Manuel Pellegrini’s side went down 4-1 to Liverpool at the Etihad in the Premier League.