Tottenham Hotspur have a number of players who are set to play at Euro 2016.
A number of Tottenham’s key talents are likely to be in the England team, while the likes of Hugo Lloris, Jan Vertonghen and Toby Alderweireld also look like shoo-ins to be at the competition, with their respective nations.
And Pochettino is concerned that his players’ international commitments could lead to fatigue, during the 2016/17 campaign.
"We have 18 internationals and every international break they go to play," he explained.
"We need to think too that a difficult summer is coming with the Euros and to manage in a good way, assess after every game to keep them fit, and avoid injuries too.
“This is a big job for us. This is a big concern for us. You need to take some important decisions and have from all the squad the commitment they are fit and can play in every competition."
It is testament to how well Spurs are playing at the moment that they have so many players representing their countries.
The Lilywhites have been unbeaten in their last 12 Premier League matches, and they appear to be one of the most dangerous teams in England.
Almost every member of Tottenham’s squad is in excellent form, and there is a great deal of excitement about the future at White Hart Lane.
Spurs have progressed considerably under Pochettino’s stewardship so far, but the Argentine boss will hope that Euro 2016 does not halt their momentum.