The former Southampton star believes that the title race will depend on the fitness of star striker Sergio Aguero.
Le Tissier has also backed Manchester United to finish second, with Arsenal and Tottenham Hotspur his picks to come third and fourth respectively.
“Well it's so tough to call right now, but it probably all comes down to one man - Sergio Aguero,” the former England international told Sky Sports.
“If he stays fit and plays for the rest of the season then City win the title, it's as simple as that. If I was running Sky Bet then I'd have them as my favourites, but it's certainly not an easy decision to make.
“I think it will be United, who just keep grinding out wins, and Arsenal just behind them with Tottenham following in the top four.”
Aguero has been on the books of City since 2011 and is arguably the best striker in the Premier League. In fact, the former Atletico Madrid star may even be the best striker in the world when he is fully fit.
The Argentina international has struggled with injuries this season, just like he has in previous years at the Etihad Stadium.
The 27-year-old former Independiente star has scored seven goals and created six chances in nine Premier League appearances so far this campaign.
Aguero has a pass accuracy of 89% and a shot accuracy of 62%, and has won three headers, 13 dribbles and one tackle.