Sunday's emphatic victory over West Ham extended Spurs' unbeaten run in the top flight to 12 games and left the side sitting fifth in the table, just two points behind Manchester City and Arsenal, and a further point adrift of Manchester United.
Despite their excellent form however, their chances of leaping into the top four have not been helped by the fact that they must travel to eastern Europe to face Qarabag in the Europa League on Thursday, before facing the Premier League champions at midday on Sunday. Pochettino admitted that it will be difficult for the squad to properly prepare for the visit of Jose Mourinho's men.
"It is true that you hand the advantage to the opponent," he said in the Daily Star.
"I laugh, I smile. Again it is like it was the week when we played Monday, Thursday and Sunday, three times in six days. And now it's the same.
"Maybe it's worse because you need to fly nearly six hours and then there is the decision about whether to come straight back or stay, it's very difficult because both decisions are bad," he added.
With surprise package Leicester City currently topping the league table, there is perhaps no better opportunity for Spurs to establish themselves among the division's top four.
While fielding a weakened team in midweek may seem like the most logical solution - given the size of the challenge awaiting them at the weekend - Pochettino will know that defeat against Qarabag could prove very costly to their hopes of progressing to the next stage in Europe.